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How Much Exome Coverage Do I Need?

If I had a nickel for every time we answered the “How much coverage is that?” question in relation to our exome sequencing services, I wouldn’t need to be writing this article.  I’d be on a boat in the Caribbean.  But, I’m not on a boat anywhere, so with all my non-boating free time I thought I would try and collect information that would help people understand which important factors to consider when doing exome sequencing.